Wednesday, 26 October 2016

OBESITY

                                               OBESITY

Annie John,
Kerala, India
Lovely Professional University

Most of the world's population live in countries where overweight and obesity kills more people than underweight. In 2014, more than 1.9 billion adults, 18 years and older, were obese. Obesity is the accumulation of excess body fat that results when energy intake exceeds energy expenditure.

Body mass index (BMI) is a measure of body fat. It is a simple index of weight for height that is commonly used to classify overweight and obesity in adults.

                                     BMI = Person's weight in kilogram/Square of height in meters
                                              = Kg/M2

For adults, WHO defines overweight and obesity as follows
                                  Overweight is a BMI  ≥ 25 and,
                                      Obesity is a BMI             ≥ 30.  


Raised BMI is a major risk factor for non-communicable diseases such as:
  • ·        Cardiovascular disease(mainly heart disease & stroke)
  • ·        Musculoskeletal disorders(especially osteoarthritis)
  •      Some cancer(including endometrial, breast, ovarian, prostate, gall-bladder, kidney and colon).


 Types of obesity

  •          Upper body obesity
  •      Lower body obesity


Upper body obesity: - Excess fat located in the central abdominal area of the body is called “apple shaped” or upper body obesity. This obesity is associated with greater risk for hypertension, insulin resistance, diabetes, dyslipidemia and corenary heart disease.

           Waist to hip ratio > 0.8 for women
           Waist to hip ratio > 1.0 for men
The abdominal depots are characterized by rapid uptake of predominately diet derived fat and high rapid turnover that is easily stimulated by adrenergic receptor activation.

Lower body obesity: - Excess fat distributed in the lower extremities around the hips is called “Pear shaped” or lower body obesity. This obesity shows opposite associations with cardiovascular disease and type 2 diabetes mellitus.
                   
                    Waist to hip ratio > 0.8 for women
                    Waist to hip ratio > 1.0 for men.


ABOUT BIOCHEMISTRY

                                           Biochemistry


Biochemistry is the study of chemical processes within and relating to living organism. " www.acs.org".




Biochemistry deals with the structures, functions and interactions of biological macromolecules, such as proteins, nuclic acids, carbohydrates and lipids, which provide the structure of cells and perform many of the functions associated with life. " Eldra (2007), p.45"


Rare Diseaes Some examples of rare diseases are  Spinal Muscular Atrophy ,   Osteogenesis imperfecta ,   Achondroplasia   or   Rett Syndrome...